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Anti-TSLPR Antibody, Non-Fucosylated (BioBet-740ZP) (CAT#: BioBet-740ZP) Datasheet

Target
TSLPR
Isotype
IgG1k
Description
ADCC-Enhanced anti-TSLPR (54C11) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Inflammatory Diseases
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced TSLPR antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CRLF2
Full Name
cytokine receptor-like factor 2
Background
This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene.
Alternative Names
CRLF2; cytokine receptor-like factor 2; CRL2; TSLPR; CRLF2Y; IL-XR; TSLP receptor; cytokine receptor CRL2 precusor; thymic stromal lymphopoietin protein receptor; thymic stromal-derived lymphopoietin receptor
Gene ID
64109
UniProt ID
Q8WTT0
Cellular Localization
Plasma membrane, Extracellular region or secreted
Involvement in Disease
Diseases associated with CRLF2 include Lymphoblastic Leukemia, Acute, With Lymphomatous Features and B-Lymphoblastic Leukemia/Lymphoma With Iamp21.
Related Pathways
Its related pathways are PEDF Induced Signaling and JAK-STAT signaling pathway.
Function
Thymus stromal lymphopoietin receptor (TSLP). It forms a functional complex with TSLP and IL7R, which can stimulate cell proliferation by activating STAT3 and STAT5. Also activate JAK2 (based on similarity). Participate in the development of the hematopoietic system.
Post-translational modifications
1.Glycosylation at Asn47, Asn55, Asn169, and Asn101 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1k
Antibody Clone
54C11
Host
Humanized
Species Reactivity
Human
Description
The binding compounds that specifically bind to human TSLPR, can be used in the treatment of inflammatory disorders.
Antibody Indication
Inflammatory Diseases

Inflammatory Diseases

Related Products

Anti-TSLPR Antibody, Non-Fucosylated (BioBet-738ZP) (CAT#: BioBet-738ZP)
Anti-TSLPR Antibody, Non-Fucosylated (BioBet-737ZP) (CAT#: BioBet-737ZP)
Anti-TSLPR Antibody, Non-Fucosylated (BioBet-739ZP) (CAT#: BioBet-739ZP)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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