Anti-TrkB Antibody, Non-Fucosylated (38B8) (CAT#: BioBet-1486ZP) Datasheet

NTRK2

neurotrophic tyrosine kinase, receptor, type 2

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

NTRK2; neurotrophic tyrosine kinase, receptor, type 2; TRKB; trk-B; GP145-TrkB; BDNF/NT-3 growth factors receptor; tyrosine kinase receptor B; tropomyosin-related kinase B; BDNF-tropomyosine receptor kinase B;

Plasma membrane, Endosome

Diseases associated with NTRK2 include Obesity, Hyperphagia, And Developmental Delay and Epileptic Encephalopathy, Early Infantile, 58.

Its related pathways are Neuroscience and ERK Pathway in Huntingtons Disease.

Receptor tyrosine kinases participate in the development and maturation of the central and peripheral nervous systems by regulating the survival, proliferation, migration, differentiation of neurons, and the formation and plasticity (through similarity) of synapses. BDNF/brain-derived neurotrophic factor and NTF4/neurotrophic factor-4 receptor. Or it can also be combined with NTF3/neurotrophin-3, which is less efficient in activating receptors, but regulates neuronal survival through NTRK2. After the ligand is bound, it undergoes homodimerization, autophosphorylation and activation. Recruit, phosphorylate and/or activate several downstream effectors, including SHC1, FRS2, SH2B1, SH2B2, and PLCG1, which regulate different overlapping signal cascades. SHC1, FRS2, SH2B1, SH2B2 activate the GRB2-Ras-MAPK cascade and regulate neural differentiation including neurite outgrowth. The Ras-PI3 kinase akt1 signal cascade is controlled by the same effector, which mainly regulates growth and survival. The plasticity of synapses is controlled through PLCG1 and downstream protein kinase c regulatory pathways. Therefore, it plays a role in learning and memory by regulating short-term synaptic function and long-term potential. PLCG1 also causes nf-kpa-b activation and transcription of genes related to cell survival. Therefore, it can inhibit anoikis, which is the apoptosis caused by the loss of cell-matrix interaction. It may also play a role in glial cell-neutrophil-dependent calcium signaling, and mediate the communication between neurons and glial cells.

Phosphorylated. Undergoes ligand-mediated autophosphorylation that is required for interaction with SHC1 and PLCG1 and other downstream effectors. Isoform TrkB-T-Shc is not phosphorylated. Ubiquitinated. Undergoes polyubiquitination upon activation; regulated by NGFR. Ubiquitination regulates the internalization of the receptor (By similarity).

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

38B8

Mouse

Human

This is secreted protein that binds with high affinity to the extracellular domain of the tropomyosin-receptor kinase B (TrkB) receptor. It promote neuronal cell survival by activating the receptor and down-stream signaling proteins. We explored anti-TrkB antibody as a therapeutic strategy for Huntington's disease (HD).

Huntington's Disease (HD)

Huntington's Disease (HD)