Target
Transmembrane protein 16A
Description
ADCC-Enhanced anti-Transmembrane protein 16A (12E11) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Transmembrane protein 16A antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Full Name
anoctamin 1, calcium activated chloride channel
Alternative Names
ANO1; anoctamin 1, calcium activated chloride channel; DOG1; TAOS2; ORAOV2; TMEM16A; anoctamin-1; Ca2+-activated Cl- channel; oral cancer overexpressed 2; tumor-amplified and overexpressed sequence 2; discovered on gastrointestinal stromal tumors protein 1; transmembrane protein 16A (eight membrane-spanning domains)
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with ANO1 include Frontal Sinus Squamous Cell Carcinoma and Frontal Sinus Cancer.
Related Pathways
Its related pathways are Neuroscience and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.
Function
Calcium-activated chloride channels (CaCC) play a role in transepithelial anion transport and smooth muscle contraction. It is necessary for the normal function of interstitial cells of Cajal (ICCs) that produce electrical pacemaker activity in the smooth muscle of the gastrointestinal tract. It is the main contributor to the basic chloride ion conductance and stimulated chloride ion conductance of airway epithelial cells, and plays an important role in the development of tracheal cartilage.
Post-translational modifications
1.Glycosylation at Asn832 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Description
The TMEM16A binding molecules find uses in diagnosis and treatment of cancer, such as gastrointestinal cancer, gastrointestinal stromal tumor, tumors of mesenchymal, epithelia, and all other cancers containing the 11 ql 3 amplification; as well as in diagnosis and treatment of other diseases, such as infections, inflammatory or immunological diseases.
Antibody Indication
Cancer
