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Creative Biolabs - ADCC+ Antibody

Anti-Transforming growth factor alpha Antibody, Non-Fucosylated (BioBet-1338ZP) (CAT#: BioBet-1338ZP) Datasheet

Target
Transforming growth factor alpha
Isotype
IgG1
Description
Anti-Transforming growth factor alpha Antibody, Non-Fucosylated (BioBet-1338ZP) is a mouse monoclonal IgG1 antibody against Transforming growth factor alpha. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Transforming growth factor alpha antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
TGFA
Full Name
transforming growth factor, alpha
Background
This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alternative Names
TGFA; transforming growth factor, alpha; TFGA; protransforming growth factor alpha; TGF-alpha
Gene ID
7039
Cellular Localization
Plasma membrane, Extracellular region or secreted
Involvement in Disease
Diseases associated with TGFA include Tooth Agenesis and Cholesteatoma Of Middle Ear.
Related Pathways
Its related pathways are Association Between Physico-Chemical Features and Toxicity Associated Pathways and NF-KappaB Family Pathway.
Function
TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
Post-translational modifications
Glycosylation at Asn25
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1
Antibody Clone
BioBet-1338ZP
Host
Mouse
Species Reactivity
Human
Description
The antibody capable of binding to transforming growth factor alpha (TGFA) can be used to treat cancer.
Antibody Indication
Cancer

Cancer

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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