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Anti-Transcobalamin Receptor Antibody, Non-Fucosylated (CAT#: BioBet-658ZP) Datasheet

Target
Transcobalamin Receptor
Isotype
IgG1
Description
Anti-Transcobalamin Receptor Antibody, Non-Fucosylated (BioBet-658ZP) is a mouse monoclonal IgG1 antibody against Transcobalamin Receptor. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Transcobalamin Receptor antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CD320
Full Name
CD320 molecule
Background
This gene encodes the transcobalamin receptor that is expressed at the cell surface. It mediates the cellular uptake of transcobalamin bound cobalamin (vitamin B12), and is involved in B-cell proliferation and immunoglobulin secretion. Mutations in this gene are associated with methylmalonic aciduria. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alternative Names
CD320; CD320 molecule; 8D6; 8D6A; TCBLR; CD320 antigen; FDC-SM-8D6; 8D6 antigen; transcobalamin receptor; FDC-signaling molecule 8D6
Gene ID
51293
UniProt ID
Q5ZPR3
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with CD320 include Methylmalonic Aciduria, Transient, Due To Transcobalamin Receptor Defect and Anal Gland Adenocarcinoma.
Related Pathways
Its related pathways are Metabolism of water-soluble vitamins and cofactors and Metabolism.
Function
Cobalamin saturated receptor (TCbl). Play an important role in the uptake of cobalamin. Plasma membrane protein: expressed on follicular dendritic cells (FDC) and mediates the interaction with germinal center B cells. As a costimulatory factor, it promotes the response of B cells to antigen stimulation; promotes the differentiation and proliferation of B cells. The germinal center-b (GC-B) cells differentiate into memory b cells and plasma cells (PC) by interacting with t cells and follicular dendritic cells (FDC). CD320 enhances the proliferation of PC precursors produced by IL-10.
Post-translational modifications
1.Glycosylation at Asn126, Asn195, and Asn213 2.Modification sites at PhosphoSitePlus 3.Ubiquitination at Lys269 and Lys278
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1
Antibody Clone
BioBet-658ZP
Host
Mouse
Species Reactivity
Human
Description
The anti-TCblR antibody can be used in any of a variety of therapeutic methods for the treatment of cancer, tumors and other proliferative diseases and disorders.
Antibody Indication
Cancer

Cancer

Related Products

Non-Fucosylated Anti-Human Transcobalamin Receptor (1 -25) Therapeutic Antibody (CAT#: BioBet-660ZP)
Non-Fucosylated Anti-Human Transcobalamin Receptor (1 -23) Therapeutic Antibody (CAT#: BioBet-659ZP)

All products and services are for Research Use Only. Do Not use in humans.

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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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