Description
Anti-TR6 Antibody, Non-Fucosylated (BioBet-1388ZP) is a mouse monoclonal IgG antibody against TR6. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced TR6 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Full Name
tumor necrosis factor receptor superfamily, member 6b, decoy
Background
This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript.
Alternative Names
TNFRSF6B; tumor necrosis factor receptor superfamily, member 6b, decoy; M68; TR6; DCR3; M68E; DJ583P15.1.1; tumor necrosis factor receptor superfamily member 6B; decoy receptor 3; decoy receptor for Fas ligand
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with TNFRSF6B include Dyskeratosis Congenita, Autosomal Recessive 5 and Dyskeratosis Congenita Autosomal Recessive.
Related Pathways
Its related pathways are TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions and TNFR1 Pathway.
Function
Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.
Field of research
Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody
Post-translational modifications
1.Glycosylation at Asn173 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Clone
BioBet-1388ZP
Description
The TR6 antibody are used for the treatment of chronic and acute inflammation, arthritis, septicemia, autoimmune diseases, transplant rejection, graft vs. host disease, infection, stroke, ischemia, acute respiratory disease syndrome, restenosis, brain injury, AIDS, Bone diseases, cancer (e. g. lymphoproliferative disorders), atheroschlerosis, and Alzheimers disease.
Antibody Indication
Cancer
