Anti-TNFSF11 Antibody, Highly Galactosylated (BioBet-GA-477ZP) (CAT#: BioBet-GA-477ZP) Datasheet

TNFSF11

TNFSF11 Gene(Protein Coding)


TNF Superfamily Member 11

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]

Denosumab; Prolia, Xgeva; 615258-40-7; AMG 162; Prolia; Xgeva; AMG 162; TNFSF11; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand superfamily member 11; CD254; ODF; OPGL; RANKL; TRANCE; osteoprotegerin ligand

Plasma membrane, Extracellular region or secreted

Its related pathways are Development_Hedgehog and PTH signaling pathways in bone and cartilage development and PEDF Induced Signaling.

Cytokines that bind to TNFRSF11B/OPG and TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Enhance the ability of dendritic cells to stimulate the proliferation of primitive T cells. It may be an important regulator of the interaction between T cells and dendritic cells, and may play a role in the regulation of T cell-dependent immune responses. It may also play an important role in enhancing bone resorption in humoral malignant hypercalcemia. Inducing osteoclastogenesis by activating a variety of signaling pathways in osteoclast precursor cells, the first thing is to bear the brunt of long-term oscillations to induce intracellular concentration of Ca(2+) leading to the activation of NFATC1, which will induce the nucleus and induce osteoclast-specific differentiation of osteoclasts. Gene transcription. In the process of osteoclast differentiation, TMEM64 and atp2a2-dependently induce the activation of CREB1 and the production of mitochondrial ROS necessary for the normal formation of osteoclasts (similarity).

Cell Biology and Cellular Response antibody; Immune System antibody

The soluble form of isoform 1 derives from the membrane form by proteolytic processing (By similarity). The cleavage may be catalyzed by ADAM17.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG2

BioBet-GA-477ZP

Human

Human

The Highly Galactosylated Anti-TNFSF11 (Denosumab), a biobetter antibody contains with a high level of galactosylation.

Postmenopausal women osteoporosis

Postmenopausal women osteoporosis