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Anti-TNFRSF8 Antibody, Non-Fucosylated (BioBet-474ZP) (CAT#: BioBet-474ZP) Datasheet

Target
TNFRSF8
Isotype
IgG1, κ
Description
Anti-TNFRSF8 Antibody, Non-Fucosylated (BioBet-474ZP) is a chimeric monoclonal IgG1, κ antibody against TNFRSF8. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Hodgkin lymphoma
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced TNFRSF8 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
TNFRSF8
Full Name
TNFRSF8 Gene(Protein Coding)


TNF Receptor Superfamily Member 8
Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Alternative Names
TNFRSF8; tumor necrosis factor receptor superfamily, member 8; CD30, D1S166E; tumor necrosis factor receptor superfamily member 8; KI 1; Ki-1 antigen; CD30L receptor; cytokine receptor CD30
Gene ID
943
UniProt ID
P28908
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with TNFRSF8 include Peripheral T-Cell Lymphoma and Reticulosarcoma.
Related Pathways
Its related pathways are TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions and Akt Signaling.
Function
Receptor for TNFSF8/CD30L (PubMed:8391933). May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.
Field of research
Cancer antibody; Immune System antibody
Post-translational modifications
Phosphorylated on serine and tyrosine residues.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1, κ
Antibody Clone
BioBet-474ZP
Host
Chimeric
Species Reactivity
Human
Description
ADCC-enhanced Brentuximab is a non-fucosylated anti-TNFRSF8 therapeutic biobetter antibody.
Antibody Indication
Hodgkin lymphoma

Hodgkin lymphoma

Related Products

Anti-TNFRSF8 Antibody, Highly Galactosylated (BioBet-GA-474ZP) (CAT#: BioBet-GA-474ZP)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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