Description
Anti-TNFRSF10A Antibody, Non-Fucosylated (BioBet-465ZP) is a human monoclonal IgG1 antibody against TNFRSF10A. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Colorectal cancers
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced TNFRSF10A antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
TNFRSF10A
Full Name
TNFRSF10A Gene(Protein Coding)
TNF Receptor Superfamily Member 10a
Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]
Alternative Names
Mapatumumab; 658052-09-6; HGS-ETR1; TRM-1; HGS-ETR1; HGS-ETR1; TNFRSF10A; tumor necrosis factor receptor superfamily, member 10a; tumor necrosis factor receptor superfamily member 10A; Apo2; CD261; DR4; TRAILR 1; TRAIL-R1; TRAIL receptor 1; death receptor 4
Gene ID
8797
UniProt ID
O00220
Cellular Localization
Plasma membrane, Cytosol
Involvement in Disease
Diseases associated with TNFRSF10A include Hirata Disease and Temporal Arteritis.
Related Pathways
Its related pathways are Apoptosis Modulation and Signaling and Signaling by GPCR.
Function
Cytotoxic ligand TNFSF10/TRAIL receptor (PubMed: 26457518). The adaptor molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signal complex (DISC) proteolytically activates caspase-8, and then initiates the caspase (aspartate-specific cysteine protease) cascade reaction to mediate cell apoptosis. Promote nf-kpa-b activation.
Field of research
Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody
Post-translational modifications
1.Palmitoylated. Palmitoylation of TNFRSF10A is required for its association with lipid rafts, oligomerization and function in TRAIL-induced cell death. Palmitoylated by ZDHHC3 (Probable). 2.Modification sites at PhosphoSitePlus 3.Glycosylation at Asn156
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1
Antibody Clone
BioBet-465ZP
Description
ADCC-enhanced Mapatumumab is a non-fucosylated anti-TNFRSF10A therapeutic biobetter antibody.
Antibody Indication
Colorectal cancers
