Anti-TNF receptor-related protein TR2 Antibody, Non-Fucosylated (CAT#: BioBet-1664ZP) Datasheet

TR2

Nuclear receptor subfamily 2, group C, member 1

TR2 is expressed in multiple human tissues and cell lines and shows a constitutive and relatively high expression in peripheral T and B lymphocytes, and monocytes. It is a member of TNF receptor family. TR2/HVEM is a receptor for herpes virus. It also acts as a receptor for LIGHT (also known as HVEM ligand), a member of TNF family. TR2 protein inhibits a mixed lymphocyte reaction mediated proliferation suggesting that the receptor and/or its ligand play a role in T cell stimulation.

TR2; Nuclear receptor subfamily 2, group C, member 1; TR2 nuclear hormone receptor; NR2C1; nuclear receptor subfamily 2, group C

Nucleus

Its related pathways are Gene Expression and Regulation of Androgen receptor activity.

Orphan nuclear receptor. Combining the IR7 element in the promoter of its own gene in an auto-regulatory negative feedback mechanism. Mainly a suppressor of multiple genes. It binds hormone response elements (HREs) composed of two 5'-AGGTCA-3' half-sites directly repeating the consensus sequence. Together with NR2C2, it forms the core DRED (direct repeat final red blood cell) complex and inhibits embryonic and fetal globin transcription. It is also an activator of OCT4 gene expression. It may be involved in the proliferation and differentiation of stem cells. Retinoic acid regulates the proliferation of pre-adipocytes.

Gene Regulation antibody

Sumoylation requires both PIAS1 and UBE2I. Sumoylation appears to dissociate NR2C1 from the PML nuclear bodies. Enhances the interaction with NRIP1 but inhibits interaction with KAT2B. In proliferating cells, stimulation by all-trans retinoic acid, activation of MAPK1-mediated phosphorylation and recruitment to PML bodies with subsequent sumoylation, suppresses OCT4 expression (By similarity). Phosphorylated on several serine and threonine residues. Phosphorylation on Thr-222, stimulated by all-trans retinoic acid (atRA) mediates PML location and sumoylation in proliferating cells which then modulates its association with effector molecules, KAT2B and NRIP1. Phosphorylation on Ser-581 by PKC is important for protein stability and function as activator of RARB (By similarity).

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-1664ZP

Rabbit

Humanized

The antibody that specifically bind to recombinant human TR2 protein can be used in related diseases of immune system.

Related Diseases of Immune System

Related Diseases of Immune System