Description
ADCC-Enhanced anti-TMPRSS2 (B20.1) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced TMPRSS2 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
TMPRSS2
Full Name
transmembrane protease, serine 2
Background
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alternative Names
TMPRSS2; transmembrane protease, serine 2; PP9284; PRSS10; transmembrane protease serine 2; epitheliasin; serine protease 10
Gene ID
7113
Cellular Localization
Plasma membrane, Extracellular region or secreted
Involvement in Disease
Diseases associated with TMPRSS2 include Covid-19 and Influenza.
Related Pathways
Its related pathways are Transcriptional misregulation in cancer and Coregulation of Androgen receptor activity.
Function
The plasma membrane anchors serine proteases and participates in the proteolytic cascade related to the normal physiological functions of the prostate. Androgen-induced TMPRSS2 activates a variety of substrates, including pre-hepatocyte growth factor/HGF, protease-activated receptor-2/F2RL1 or matrix enzyme/ST14, leading to the destruction of extracellular matrix and the metastasis of prostate cancer cells. In addition, it can activate trigeminal neurons and promote spontaneous pain and mechanical ectopic pain (through similarity). (Microbial infection) Two independent mechanisms that promote human coronavirus SARS-CoV and SARS-CoV-2 infection are proteolytic cleavage of the ACE2 receptor to promote virus uptake, and cleavage of the lytic coronavirus spike glycoprotein activates glycoprotein to enter host cells. Cut and activate the peak glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) through proteolysis, as well as Sendai virus (SeV), human metapneumovirus (HMPV), and human parainfluenza The fusion glycoprotein F0 of viruses 1, 2, 3, 4a and 4b (HPIV). The transmission and pathogenesis of influenza A virus (H1N1, H3N2 and H7N9 strains); it participates in the proteolysis and activation of hemagglutinin (HA) protein, which is essential for virus infectivity.
Post-translational modifications
1.Proteolytically processed; by an autocatalytic mechanism 2.Modification sites at PhosphoSitePlus 3.Glycosylation at Asn213 and Asn249
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1k
Antibody Clone
B20.1
Description
The anti-Pro115 antibody that bind to Pro115 are used in treating Pro115-expressing cancers such as prostate, colon, lung or pancreas cancers.
Antibody Indication
Cancer
