Description
Anti-Tissue factor pathway inhibitor Antibody, Non-Fucosylated (BioBet-1335ZP) is a human monoclonal IgG antibody against Tissue factor pathway inhibitor. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Hemophilia
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Tissue factor pathway inhibitor antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
TFPI
Full Name
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
Background
This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed.
Alternative Names
TFPI; tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor); EPI; TFI; LACI; TFPI1; tissue factor pathway inhibitor; anti-convertin; extrinsic pathway inhibitor
Gene ID
7035
Cellular Localization
Extracellular region or secreted, Endoplasmic reticulum
Involvement in Disease
Diseases associated with TFPI include Thrombosis and Hemophilia.
Related Pathways
Its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Response to elevated platelet cytosolic Ca2+.
Function
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
Field of research
Cell Biology and Cellular Response antibody
Post-translational modifications
O-glycosylated.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
4B7
Description
The monoclonal antibody that bind human tissue factor pathway inhibitor (TFPI) are used for treatment of genetic and acquired deficiencies or defects in coagulation such as hemophilia A and B.
Antibody Indication
Hemophilia
