Description
Anti-TIRC7 Antibody, Non-Fucosylated (BioBet-1325ZP) is a chimeric monoclonal IgG antibody against TIRC7. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Rheumatoid Arthritis
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced TIRC7 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
TCIRG1
Full Name
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
Background
Through alternate splicing, this gene encodes two proteins with similarity to subunits of the vacuolar ATPase (V-ATPase) but the encoded proteins seem to have different functions. V-ATPase is a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Mutations in this gene are associated with infantile malignant osteopetrosis.
Alternative Names
TCIRG1; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3; a3; Stv1; Vph1; Atp6i; OC116; OPTB1; TIRC7; ATP6N1C; ATP6V0A3; OC-116kDa; V-type proton ATPase 116 kDa subunit a isoform 3; OC-116 kDa; V-ATPase 116-kDa; T-cell immune response cDNA 7; ATPase, H+ transporting, 116kD; V-type proton ATPase 116 kDa subunit a; osteoclastic proton pump 116 kDa subunit; specific 116-kDa vacuolar proton pump subunit; vacuolar proton translocating ATPase 116 kDa subunit A; T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a
Gene ID
10312
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with TCIRG1 include Osteopetrosis, Autosomal Recessive 1 and Autosomal Recessive Malignant Osteopetrosis.
Related Pathways
Its related pathways are Lysosome and Synaptic vesicle cycle.
Function
Part of the proton channel of V-ATPases (By similarity). Seems to be directly involved in T-cell activation.
Post-translational modifications
1.Modification sites at neXtProt 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
Neliximab
Description
The anti-TIRC7 antibody can be used for the treatment of an inflammatory disease, particularly rheumatoid arthritis.
Antibody Indication
Rheumatoid Arthritis
