Description
ADCC-Enhanced anti-TIMP1 (MS-BW-14) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Liver Fibrosis; Alcoholic Liver Disease; Cardiac Fibrosis
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced TIMP1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Full Name
TIMP metallopeptidase inhibitor 1
Background
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.
Alternative Names
TIMP1; TIMP metallopeptidase inhibitor 1; EPA; EPO; HCI; CLGI; TIMP; metalloproteinase inhibitor 1; TIMP-1; collagenase inhibitor; erythroid potentiating activity; erythroid-potentiating activity; fibroblast collagenase inhibitor; tissue inhibitor of metalloproteinases 1
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with TIMP1 include Oral Submucous Fibrosis and Lung Giant Cell Carcinoma.
Related Pathways
Its related pathways are G-protein signaling Ras family GTPases in kinase cascades (scheme) and Degradation of the extracellular matrix.
Function
The metalloproteinase inhibitor forms a one-to-one complex with the target metalloprotease such as collagenase, and binds to its catalytic zinc cofactor to irreversibly inactivate it. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not work for MMP14. It can also be used as a growth factor to regulate cell differentiation, migration and cell death, and activate the cell signaling cascade through CD63 and ITGB1. It plays a role in integrin signaling. Mediates red blood cell production in vitro; however, unlike IL3, it is species-specific and only stimulates the growth and differentiation of human and mouse red blood cell progenitor cells.
Post-translational modifications
The activity of TIMP1 is dependent on the presence of disulfide bonds. N-glycosylated.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Description
The human antibody that bind to TIMP-1 can be used as reagents to diagnose and treat disorders in which TIMP-1 is elevated, such as liver fibrosis, alcoholic liver disease, cardiac fibrosis, acute coronary syndrome, lupus nephritis, glomerulosclerotic renal disease, benign prostate hypertrophy, colon cancer, lung cancer, and idiopathic pulmonary fibrosis.
Antibody Indication
Liver Fibrosis; Alcoholic Liver Disease; Cardiac Fibrosis
