Anti-TIM-3 Antibody, Non-Fucosylated (BioBet-1345ZP) (CAT#: BioBet-1345ZP) Datasheet

TIM3

T-cell immunoglobulin and mucin domain containing molecule-3

T cell immunoglobulin and mucin-domain-containing molecule-3 (Tim-3) has been shown to influence autoimmune diseases; however, its function in viral infection has not been well-defined.

T-cell immunoglobulin and mucin domain containing molecule-3; TIM3

Plasma membrane

Diseases associated with HAVCR2 include T-Cell Lymphoma, Subcutaneous Panniculitis-Like and Panniculitis.

Its related pathways are RET signaling and Innate Immune System.

Cell surface receptors are involved in the regulation of innate and adaptive immune responses. Generally considered to have an inhibitory effect. Reports on stimulating function indicate that this activity may be affected by the cellular environment and/or the respective ligands. Regulates the activation of macrophages. Inhibit T-helper type 1 lymphocytes (Th1) mediated self and allogeneic immune responses and promote immune tolerance. CD8+ cells attenuate the signal pathway induced by tcr, especially by blocking the activity of NF-kappaB and NFAT promoters leading to a decrease in IL-2 secretion. This function may be related to LCK, which can disrupt the phosphorylation of TCR subunits and/or the recruitment of lgals9-dependent PTPRC to immune synapses. In contrast, the activation of tcr-induced signaling pathways in T cells may involve ZAP70, LCP2, LCK and FYN (similarities). Expression on Treg cells can inhibit Th17 cell response. LGALS9 receptor. Binding with LGALS9 is thought to inhibit the response of t cells; the resulting antigen-specific cell apoptosis may be related to the phosphorylation of HAVCR2 and the interruption of its relationship with BAG6. Binding to LGALS9 is believed to be involved in the innate immune response to intracellular pathogens. LGALS9 expressed on Th1 cells interacts with LGALS9 expressed on Mycobacterium tuberculosis-infected macrophages, stimulating antibacterial activity including IL-1 secretion, and limiting the growth of intracellular bacteria (by similarity). However, the function of the LGALS9 receptor has been challenged. It has also been reported to enhance the response of CD8+ t cells to acute infections, such as Listeria monocytogenes (similarity). Phosphatidylserine receptor; PtSer-binding calcium-dependent. It can recognize PtSer on apoptotic cells, leading to phagocytosis. Mediates the phagocytosis of apoptotic cells by dendritic cells. Expressed on T cells to promote coupling without phagocytosis of apoptotic cells. Dendritic cell (dc) expression positively regulates the innate immune response, and cooperates with toll-like receptors to promote the secretion of tnf -. In tumors, infiltrating dendritic cells interact with HMGB1 to interfere with nucleic acid sensing and nucleic acid transport to endosomes (through similarity), thereby inhibiting nucleic acid-mediated innate immune responses. Expressed on natural killer cells (NK), as a co-receptor, it enhances the production of IFN-gamma under the action of LGALS9. On the contrary, it can inhibit NK cell-mediated cytotoxicity. Negatively regulate NK cell function in lipopolysaccharide-induced endotoxin shock (similar).

Immune System antibody

O-glycosylated with core 1 or possibly core 8 glycans. Phosphorylated on tyrosine residues; modestly increased after TCR/CD28 stimulation. Can be phosphorylated in the cytoplasmatic domain by FYN (By similarity). Phosphorylation at Tyr-265 is increased by stimulation with ligand LGALS9.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-1345ZP

Chimeric

Human

The antibody specific for TIM3 can be used to detect cancer cells, in particular, cancer stem cells. The antibody can also be used in therapeutic compositions for treating cancer and reducing inflammation.

Cancer

Cancer