Description
Anti-Tie-1 receptor Antibody, Non-Fucosylated (BioBet-1344ZP) is a human monoclonal IgG antibody against Tie-1 receptor. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Tie-1 receptor antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
TIE1
Full Name
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Background
This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Alternative Names
TIE1; tyrosine kinase with immunoglobulin-like and EGF-like domains 1; TIE; JTK14; tyrosine-protein kinase receptor Tie-1; tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1
Gene ID
7075
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with TIE1 include Angiosarcoma and Arteriovenous Malformation.
Related Pathways
Its related pathways are Immune response IL-23 signaling pathway and Activation of cAMP-Dependent PKA.
Function
Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.
Post-translational modifications
Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1344ZP
Description
DX-2240 is a fully human monoclonal antibody that targets the Tie-1 receptor on tumor blood vessels and has therapeutic potential in numerous oncology indications. In preclinical animal models, DX-2240 has demonstrated activity against a broad range of solid tumor types.
Antibody Indication
Cancer
