Description
ADCC-Enhanced anti-Thyroid stimulating hormone (TSH) receptor (KSAb2) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Thyroid Tumor
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Thyroid stimulating hormone (TSH) receptor antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
TSHR
Full Name
thyroid stimulating hormone receptor
Background
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
Alternative Names
TSHR; thyroid stimulating hormone receptor; LGR3; CHNG1; hTSHR-I; thyrotropin receptor; thyrotropin receptor-I, hTSHR-I; seven transmembrane helix receptor; thyroid stimulating hormone receptor, isoform 2
Gene ID
7253
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with TSHR include Hypothyroidism, Congenital, Nongoitrous, 1 and Hyperthyroidism, Familial Gestational.
Related Pathways
Its related pathways are Signaling by GPCR and Thyroxine (Thyroid Hormone) Production.
Function
Thyroid-stimulating hormone (TSH) or thyroid-stimulating hormone receptor. Also used as heterodiglycan protein hormone (GPHA2: GPHB5) or thyroid hormone receptor. The activity of this receptor is mediated by G protein, which activates adenylate cyclase. Plays a central role in controlling the metabolism of thyroid cells (through similarity).
Post-translational modifications
Glycosylated. Sulfated. Sulfation on Tyr-385 plays a role in thyrotropin receptor binding and activation.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
KSAb2
Description
The antibody that bind the thyroid stimulating hormone receptor (TSHR) are used in treatment for cancer of the thyroid.
Antibody Indication
Thyroid Tumor
