Description
Anti-TG2 Antibody, Non-Fucosylated (BioBet-1342ZP) is a human monoclonal IgG antibody against TG2. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Celiac Disease; Scarring, Fibrosis-related Diseases; Neurodegenerative/Neurological Diseases; Cancer
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced TG2 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Full Name
transglutaminase 2
Background
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene.
Alternative Names
TGM2; transglutaminase 2; TG2; TGC; GNAH; HEL-S-45; G-ALPHA-h; protein-glutamine gamma-glutamyltransferase 2; TG(C); TGase C; TGase H; TGase-2; TGase-H; transglutaminase C; transglutaminase H; transglutaminase-2; tissue transglutaminase; epididymis secretory protein Li 45; protein-glutamine-gamma-glutamyltransferase; C polypeptide, protein-glutamine-gamma-glutamyltransferase
Cellular Localization
Plasma membrane, Extracellular region or secreted, Endoplasmic reticulum, Endoplasmic reticulum, Cytosol
Involvement in Disease
Diseases associated with TGM2 include Dermatitis Herpetiformis and Balanitis Xerotica Obliterans.
Related Pathways
Its related pathways are Parkinson disease and Ca, cAMP and Lipid Signaling.
Function
Catalyzes the cross-linking of proteins, such as WDR54, and the conjugation of polyamines to proteins.
Field of research
Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody; Metabolism antibody; Signaling Transduction antibody
Post-translational modifications
1.Modification sites at neXtProt 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Clone
BioBet-1342ZP
Description
The antibody that selectively bind to an epitope within the core region of transglutaminase type 2 (TG2). used in the treatment conditions including Celiac disease, scarring, fibrosis-related diseases, neurodegenerative/neurological diseases and cancer.
Antibody Indication
Celiac Disease; Scarring, Fibrosis-related Diseases; Neurodegenerative/Neurological Diseases; Cancer
