Description
Anti-Tenascin C Antibody, Non-Fucosylated (BioBet-1373ZP) is a human monoclonal IgG antibody against Tenascin C. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Hematologic Malignancies; Solid Tumors
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Tenascin C antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Background
This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration.
Alternative Names
TNC; tenascin C; GP; JI; TN; HXB; GMEM; TN-C; DFNA56; 150-225; tenascin; GP 150-225; cytotactin; neuronectin; myotendinous antigen; hexabrachion (tenascin); tenascin-C isoform 14/AD1/16; tenascin-C additional domain 1; deafness, autosomal dominant 56; glioma-associated-extracellular matrix antigen
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with TNC include Deafness, Autosomal Dominant 56 and Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna.
Related Pathways
Its related pathways are Neuroscience and Integrin Pathway.
Function
Extracellular matrix proteins guide the migration of neurons and axons, synaptic plasticity and neuron regeneration during development. Promote neurite outgrowth of cortical neurons that grow on a monolayer of astrocytes. Ligands for integrins a-8/ -1, a-9/ -1, a-v / -3 and a-v / -6. In tumors, angiogenesis is stimulated by the extension, migration and sprouting of endothelial cells.
Field of research
Cell Biology and Cellular Response antibody; Signaling Transduction antibody
Post-translational modifications
1.Glycosylation at Asn38, Asn166, Asn184, Asn327, Asn788, Asn1018, Asn1034, Asn1079, Asn1445, Asn1455, Asn1093, Asn1119, Asn1485, Asn1534, Asn1809, Asn1184, Asn1210, Asn1261, Asn1275, Asn1301, Asn1366, Asn1392, and Asn2162 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Description
The monoclonal antibody F16-131I specific to F16 (specific to the A1 domain of tenascin-C) are currently investigated in Phase I and Phase II clinical trials in patients with cancer and with rheumatoid arthritis.
Antibody Indication
Hematologic Malignancies; Solid Tumors
