Description
Anti-TEM8 Antibody, Non-Fucosylated (BioBet-567ZP) is a human monoclonal IgG1k antibody against TEM8. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced TEM8 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
ANTXR1
Full Name
anthrax toxin receptor 1
Background
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.
Alternative Names
ANTXR1; anthrax toxin receptor 1; ATR; GAPO; TEM8; 2310008J16Rik; 2810405N18Rik; tumor endothelial marker 8
Gene ID
84168
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with ANTXR1 include Gapo Syndrome and Tetramelic Deficiencies, Ectodermal Dysplasia, Deformed Ears, And Other Abnormalities.
Related Pathways
Its related pathways are Cellular roles of Anthrax toxin and Uptake and actions of bacterial toxins.
Function
Play a role in cell attachment and migration. Interacts with extracellular matrix proteins and actin cytoskeleton. It mediates the adhesion of cells to type 1 collagen and gelatin, reorganizes the actin cytoskeleton, and promotes cell proliferation. Participate in the angiogenesis of cultured umbilical vein endothelial cells.
Field of research
Cell Biology and Cellular Response antibody; Controls and Markers antibody; Microbiology and Infectious Disease antibody
Post-translational modifications
1.Glycosylation at Asn166, Asn184, and Asn262 2.Modification sites at PhosphoSitePlus 3.Ubiquitination at Lys445 and Lys45
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1k
Antibody Clone
BioBet-567ZP
Description
antibody that specifically bind TEM8 protein are useful for detecting and treating cancer.
Antibody Indication
Cancer
