Description
Anti-TATA-binding protein-associated factor 15 Antibody, Non-Fucosylated (BioBet-1319ZP) is a human monoclonal IgG antibody against TATA-binding protein-associated factor 15. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced TATA-binding protein-associated factor 15 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
TAF15
Full Name
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
Background
This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Alternative Names
TAF15; TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa; Npl3; RBP56; TAF2N; TAFII68; TATA-binding protein-associated factor 2N; RBP56/CSMF fusion; TBP-associated factor 15; TATA box-binding protein-associated factor 2N (RNA-binding protein 56); TATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA-binding protein 56)
Gene ID
8148
Cellular Localization
Nucleus
Involvement in Disease
Diseases associated with TAF15 include Chondrosarcoma, Extraskeletal Myxoid and Myxoid Chondrosarcoma.
Related Pathways
Its related pathways are Transcriptional misregulation in cancer and RNA Polymerase II Transcription Initiation And Promoter Clearance.
Function
RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II).
Post-translational modifications
Dimethylated by PRMT1 at Arg-206 to asymmetric dimethylarginine. The methylation may favor nuclear localization and positive regulation of TAF15 transcriptional activity. ADP-ribosylated during genotoxic stress.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1319ZP
Description
The antibody pertaining to TATA-binding protein-associated factor 15 (TAF 15) are useful in treatment for inhibiting growth or proliferation of proliferating cells, such as hyperproliferative cells or inducing regression of hyperproliferative cells, such as cells of a cellular hyperproliferative disorder.
Antibody Indication
Cancer
