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Anti-TAT188 Antibody, Non-Fucosylated (BioBet-1620ZP) (CAT#: BioBet-1620ZP) Datasheet

Target
TAT188
Isotype
IgG
Description
Anti-TAT188 Antibody, Non-Fucosylated (BioBet-1620ZP) is a humanized monoclonal IgG antibody against TAT188. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced TAT188 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
HER2
Full Name
Epidermal growth factor receptor 2 (HER2)
Background
HER2 protein overexpression is observed in 25-30% of primary breast cancers.
Alternative Names
HER2; Epidermal growth factor receptor 2 (HER2)
Cellular Localization
Plasma membrane, Endosome, Nucleus
Involvement in Disease
Diseases associated with ERBB2 include Glioma Susceptibility 1 and Gastric Cancer.
Related Pathways
Its related pathways are Association Between Physico-Chemical Features and Toxicity Associated Pathways and RET signaling.
Function
Protein tyrosine kinases are part of several cell surface receptor complexes, but obviously require a co-receptor to which a ligand binds. An essential component of the neurotonin receptor complex, although neurotonin does not interact with it alone. GP30 is a potential ligand for this receptor. Regulate the growth and stability of peripheral microtubules (MTs). After ERBB2 is activated, the memo1-rhoa-991 signaling pathway triggers the phosphorylation of GSK3B on the cell membrane, thereby inhibiting GSK3B. This prevents the phosphorylation of APC and CLASP2, allowing them to bind to the cell membrane. In turn, membrane-bound APC allows MACF1 to localize to the cell membrane, which is necessary for microtubule capture and stabilization.
Field of research
Cancer antibody; Controls and Markers antibody; Signaling Transduction antibody; Circulating Tumor Cells BioMarker antibody
Post-translational modifications
Autophosphorylated. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit (Probable). Ligand-binding increases phosphorylation on tyrosine residues. Signaling via SEMA4C promotes phosphorylation at Tyr-1248. Dephosphorylated by PTPN12.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1620ZP
Host
Humanized
Species Reactivity
Human
Description
Anti-TAT188 antibody that selectively binds to the extracellular domain of the human epidermal growth factor receptor 2 (HER2) proto-oncogene are useful for the diagnosis and treatment of tumor in mammals.
Antibody Indication
Cancer

Cancer

Related Products

Anti-TAT188 Antibody, Non-Fucosylated (BioBet-1622ZP) (CAT#: BioBet-1622ZP)
Anti-TAT188 Antibody, Non-Fucosylated (BioBet-1621ZP) (CAT#: BioBet-1621ZP)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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