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Anti-System ASC amino acid transporter 2 Antibody, Non-Fucosylated (cKM4018) (CAT#: BioBet-1290ZP) Datasheet

Target
System ASC amino acid transporter 2
Isotype
IgG
Description
ADCC-Enhanced anti-System ASC amino acid transporter 2 (cKM4018) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced System ASC amino acid transporter 2 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
SLC1A5
Full Name
solute carrier family 1 (neutral amino acid transporter), member 5
Background
The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus (Larriba et al., 2001 ).
Alternative Names
SLC1A5; solute carrier family 1 (neutral amino acid transporter), member 5; R16; AAAT; ATBO; M7V1; RDRC; ASCT2; M7VS1; neutral amino acid transporter B(0); ATB(0); RD114 virus receptor; baboon M7 virus receptor; neutral amino acid transporter B; solute carrier family 1 member 5; RD114/simian type D retrovirus receptor; sodium-dependent neutral amino acid transporter type 2
Gene ID
6510
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with SLC1A5 include Hartnup Disorder and Placental Choriocarcinoma.
Related Pathways
Its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Collagen chain trimerization.
Function
Sodium-dependent amino acid transporter, with broad substrate specificity, prefers zwitterionic amino acids. It accepts all neutral amino acids as substrates, including glutamine, asparagine, branched chain amino acids and aromatic amino acids, but does not include methylated, anionic and cationic amino acids. The syncytin1/ERVW-1 fusion protein may mediate the syncytization of trophoblasts, that is, the spontaneous fusion of their plasma membranes, which is an important process of placental development. Microbial infection) as the cell surface receptor of the cat endogenous virus RD114. (Microbial infection) As the cell surface receptor of baboon M7 endogenous virus. (Microbial infection) As the cell surface receptor of D type simian retrovirus.
Post-translational modifications
1.Glycosylation at Asn212 and Asn163 2.Modification sites at PhosphoSitePlus 3.Ubiquitination at Lys372, Lys502, Lys522, and Lys537
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
cKM4018
Host
Chimeric
Species Reactivity
Human
Description
This is a monoclonal antibody which specifically recognizes the ASC amino acid transporter 2 system (ASCT2), used for colorectal cancer, liver cancer, breast cancer, astrocytoma and neuroblastoma.
Antibody Indication
Cancer

Cancer

Related Products

Anti-System ASC amino acid transporter 2 Antibody, Non-Fucosylated (cKM4012) (CAT#: BioBet-1289ZP)
Anti-System ASC amino acid transporter 2 Antibody, Non-Fucosylated (cKM4008) (CAT#: BioBet-1291ZP)

All products and services are for Research Use Only. Do Not use in humans.

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