Description
Anti-STEAP-1 Antibody, Non-Fucosylated (BioBet-1314ZP) is a mouse monoclonal IgG2aκ antibody against STEAP-1. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Prostate Cancer
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced STEAP-1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
STEAP1
Full Name
six transmembrane epithelial antigen of the prostate 1
Background
This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions.
Alternative Names
STEAP1; six transmembrane epithelial antigen of the prostate 1; STEAP; PRSS24; metalloreductase STEAP1; six-transmembrane epithelial antigen of prostate 1
Gene ID
26872
Cellular Localization
Endosome
Involvement in Disease
Diseases associated with STEAP1 include Ewing Sarcoma and Aceruloplasminemia.
Related Pathways
Its related pathways are Copper homeostasis and Mineral absorption.
Function
Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor.
Post-translational modifications
1.Modification sites at neXtProt 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG2aκ
Antibody Clone
BioBet-1314ZP
Description
The monoclonal antibody against to six-transmembrane epithelial antigen of the prostate-1 (STEAP-1) can inhibit intercellular communication in vitro and growth of human tumor xenografts in vivo.
Antibody Indication
Prostate Cancer
