Description
Anti-sPLA2-IIA Antibody, Non-Fucosylated (BioBet-1501ZP) is a Rabbit monoclonal IgG antibody against sPLA2-IIA. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Inflammation; Atherosclerosis
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced sPLA2-IIA antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Full Name
phospholipase A2, group IIA (platelets, synovial fluid)
Background
The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5 UTRs have been found for this gene.[provided by RefSeq, Sep 2009]
Alternative Names
PLA2G2A; phospholipase A2, group IIA (platelets, synovial fluid); MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1; sPLA2; phospholipase A2, membrane associated; NPS-PLA2; GIIC sPLA2; group IIA phospholipase A2; phosphatidylcholine 2-acylhydrolase 2A; non-pancreatic secretory phospholipase A2;
Cellular Localization
Plasma membrane, Extracellular region or secreted
Involvement in Disease
Diseases associated with PLA2G2A include Colorectal Cancer and Gas Gangrene.
Related Pathways
Its related pathways are Sweet Taste Signaling and Acyl chain remodelling of PE.
Function
Secretion of calcium-dependent phospholipase A2 mainly acts on extracellular phospholipids and plays a role in host antibacterial defense, inflammatory response and tissue regeneration. Hydrolysis of the ester bond of the fatty acyl group (phospholipase A2 activity) attached to the sn-2 position of the phospholipid prefers phosphatidylethanolamine and phosphatidylglycerol over phosphatidylcholine. Contribute to lipid remodeling of cell membranes and production of lipid mediators to participate in pathogen clearance. It has bactericidal activity against Gram-positive bacteria by directly hydrolyzing the phospholipids of bacterial membranes. Under aseptic inflammation, the target is the extracellular mitochondrial membrane phospholipids released by activated platelets to generate free unsaturated fatty acids, such as arachidonic acid, which are used by neighboring white blood cells to synthesize inflammatory eicosanoids, such as white three Ene. At the same time, by damaging the integrity of the mitochondrial membrane, it promotes the release of effective damage-related molecular pattern molecules in the circulation and activates the innate immune response. It plays a role in regulating stem cells in the intestinal crypts. In the cell, it mediates the differentiation of Paneth cells and their stem cell support function by inhibiting the Wnt signaling pathway of intestinal stem cells. Secreted in the intestinal lumen during inflammation, autocrine, promote the synthesis of prostaglandin E2, stimulate the Wnt signaling pathway in ICS cells and tissue regeneration (similar). It may be involved in the biosynthesis of n-acylethanolamine, regulating energy metabolism and inflammation. The n-acylphosphatidylethanolamine is hydrolyzed to n-acyl lysophosphatidylethanolamine, which is further cleaved by lysophospholipase D to release n-acylethanolamine. Independent of catalytic activity, as a ligand for integrins. Combines and activates the integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1. Binding to a site (site 2) different from the classic ligand binding site (site 1) induces conformational changes of the integrin and enhances the binding of the ligand to site 1. Induce cell proliferation in an integrin-dependent manner.
Post-translational modifications
1.Modification sites at neXtProt 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Clone
BioBet-1501ZP
Description
It is an isolated antibody against human sPLA2-IIA which play a key role in various biological processes including homeostasis of cellular membranes, lipid digestion, host defense, signal transduction, and production of lipid mediators. Therefore, it can be used in inflammation and atherosclerosis.
Antibody Indication
Inflammation; Atherosclerosis
