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Anti-Sodium channel subunit beta-2 Antibody, Non-Fucosylated (BioBet-1262ZP) (CAT#: BioBet-1262ZP) Datasheet

Target
Sodium channel subunit beta-2
Isotype
IgG
Description
Anti-Sodium channel subunit beta-2 Antibody, Non-Fucosylated (BioBet-1262ZP) is a humanized monoclonal IgG antibody against Sodium channel subunit beta-2. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Alzheimer's Disease
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Sodium channel subunit beta-2 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
SCN2B
Full Name
sodium channel, voltage gated, type II beta subunit
Alternative Names
SCN2B; sodium channel, voltage gated, type II beta subunit; ATFB14; sodium channel subunit beta-2; sodium channel beta 2 subunit; neuronal voltage-gated sodium channel beta 2 subunit; sodium channel, voltage-gated, type II, beta subunit; sodium channel, voltage-gated, type II, beta polypeptide
Gene ID
6327
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with SCN2B include Atrial Fibrillation, Familial, 14 and Familial Atrial Fibrillation.
Related Pathways
Its related pathways are Neuroscience and Activation of cAMP-Dependent PKA.
Function
The key to the assembly, expression and functional regulation of sodium channel heterotrimers. Subunit-2 causes an increase in the surface area of the plasma membrane and causes it to fold into microvilli. The interaction with TNR may play an important role (through similarity) in the clustering and regulation of Ranvier node sodium channels.
Post-translational modifications
1.Glycosylation at Asn42, Asn66, and Asn74 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1262ZP
Host
Humanized
Species Reactivity
Human
Description
The antibody bind to SCN2B are used for diagnosing or prognosticating a neurodegenerative disease, in particular Alzheimer's disease.
Antibody Indication
Alzheimer's Disease

Alzheimer's Disease

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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