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Anti-SLAM family member 7 Antibody, Non-Fucosylated (BioBet-1288ZP) (CAT#: BioBet-1288ZP) Datasheet

Target
SLAM family member 7
Isotype
IgG
Description
Anti-SLAM family member 7 Antibody, Non-Fucosylated (BioBet-1288ZP) is a humanized monoclonal IgG antibody against SLAM family member 7. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Autoimmune Diseases
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced SLAM family member 7 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
SLAMF7
Full Name
SLAM family member 7
Alternative Names
SLAMF7; SLAM family member 7; 19A; CS1; CD319; CRACC; protein 19A; CD2 subset 1; 19A24 protein; membrane protein FOAP-12; CD2-like receptor activating cytotoxic cells; CD2-like receptor-activating cytotoxic cells; novel LY9 (lymphocyte antigen 9) like protein
Gene ID
57823
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with SLAMF7 include Smoldering Myeloma and Submandibular Gland Disease.
Related Pathways
Its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.
Function
Self-ligand receptor of the signaling lymphocyte activation molecule (SLAM) family. The SLAM receptor triggered by the homo- or heterotypic cell-cell interaction regulates the activation and differentiation of various immune cells, and therefore participates in the regulation and interconnection of innate immune response and adaptive immune response. Activity is controlled by the presence or absence of small cytoplasmic adaptor proteins SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through an erk-mediated pathway that is independent of sh2d1's extracellular signal regulation. By relying on the phosphorylated SH2D1B mechanism, it positively regulates the function of NK cells. The downstream signals involve PLCG1, PLCG2 and PI3K. In addition to the interaction between heterotypic NK cells and target cells, homotypic interactions between NK cells may also contribute to activation. However, in the absence of SH2D1B, NK cell function will be inhibited. It also has an inhibitory effect on T cells (similar). May be involved in lymphocyte adhesion. Monocytes activated by lipopolysaccharide negatively regulate the production of pro-inflammatory cytokines.
Post-translational modifications
1.Glycosylation at Asn142, Asn148, Asn172, Asn176, Asn204, and Asn98 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1288ZP
Host
Humanized
Species Reactivity
Human
Description
PDL241 is a novel humanized monoclonal antibody to CD319, used as a therapeutic target for rheumatoid arthritis.
Antibody Indication
Autoimmune Diseases

Autoimmune Diseases

All products and services are for Research Use Only. Do Not use in humans.

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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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