Description
Anti-Signal-regulatory protein alpha Antibody, Non-Fucosylated (BioBet-1287ZP) is a humanized monoclonal IgG antibody against Signal-regulatory protein alpha. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Hematologic malignancies
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Signal-regulatory protein alpha antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
SIRPA
Full Name
signal-regulatory protein alpha
Background
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.
Alternative Names
SIRPA; signal-regulatory protein alpha; BIT; MFR; P84; SIRP; MYD-1; SHPS1; CD172A; PTPNS1; tyrosine-protein phosphatase non-receptor type substrate 1; myd-1 antigen; inhibitory receptor SHPS-1; macrophage fusion receptor; CD172 antigen-like family member A; tyrosine phosphatase SHP substrate 1; brain-immunoglobulin-like molecule with tyrosine-based activation motifs
Gene ID
140885
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with SIRPA include Suppression Amblyopia and Bladder Neck Obstruction.
Related Pathways
Its related pathways are Cell surface interactions at the vascular wall and Tyrosine Kinases / Adaptors.
Function
CD47 immunoglobulin-like cell surface receptor. As a docking protein, it induces the translocation of binding substances such as PTPN6 and PTPN11 from the cytoplasm to the plasma membrane. Supports the adhesion of cerebellar neurons, the growth of neurites and the adhesion of glial cells. May play a key role (through similarity) in intracellular signaling of synapse occurrence and synaptic function. Participate in the negative regulation of cell adhesion, growth factor or insulin-induced receptor tyrosine kinase coupled cell response. Mediates the negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding can prevent the maturation of immature dendritic cells and inhibit the production of cytokines by mature dendritic cells.
Field of research
Cell Biology and Cellular Response antibody; Neuroscience antibody; Cardiomyocyte Cell Surface Marker antibody
Post-translational modifications
N-glycosylated. Phosphorylated on tyrosine residues in response to stimulation with EGF, growth hormone, insulin and PDGF. Dephosphorylated by PTPN11.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1287ZP
Description
The anti-SIRPA antibody are used for treating hematological cancer.
Antibody Indication
Hematologic malignancies
