Description
Anti-SEMA3A Antibody, Non-Fucosylated (BioBet-1269ZP) is a humanized monoclonal IgG antibody against SEMA3A. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Neurodegenerative Disease; Autoimmune Disease; Inflammatory Disease; Cancer; Infectious Disease
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced SEMA3A antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Full Name
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
Background
This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimers disease.
Alternative Names
SEMA3A; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A; HH16; SemD; COLL1; SEMA1; SEMAD; SEMAL; coll-1; Hsema-I; SEMAIII; Hsema-III; semaphorin-3A; collapsin 1; semaphorin D; semaphorin L; semaphorin III
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with SEMA3A include Hypogonadotropic Hypogonadism 16 With Or Without Anosmia and Kallmann Syndrome.
Related Pathways
Its related pathways are Semaphorin interactions and Guidance Cues and Growth Cone Motility.
Function
Participate in the development of the olfactory system and neural control during adolescence. Induce the breakdown and paralysis of nerve growth cones. It can be used as a ligand to guide specific growth cones through a motif inhibition mechanism. Binds to the complex neuroprotein 1/plexin 1.
Post-translational modifications
1.Glycosylation at Asn53, Asn125, and Asn590 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Clone
BioBet-1269ZP
Description
The anti-Sema3A antibody enables effective prevention and treatment of a disease, in which Sema3A protein participates, such as a neurodegenerative disease, autoimmune disease, inflammatory disease, cancer, infectious disease, etc. or disseminated intravascular coagulation syndrome.
Antibody Indication
Neurodegenerative Disease; Autoimmune Disease; Inflammatory Disease; Cancer; Infectious Disease
