Target
Secreted frizzled related protein type 4
Description
Anti-Secreted frizzled related protein type 4 Antibody, Non-Fucosylated (BioBet-1282ZP) is a Rabbit monoclonal IgG antibody against Secreted frizzled related protein type 4. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer; Heart Failure; Myocardial Infarction; Stroke
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Secreted frizzled related protein type 4 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Full Name
secreted frizzled-related protein 4
Background
Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression.
Alternative Names
SFRP4; secreted frizzled-related protein 4; FRP-4; FRPHE; sFRP-4; frizzled protein, human endometrium; secreted frizzled-related protein 4; secreted frizzled-related protein 4
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with SFRP4 include Pyle Disease and Osteomalacia.
Related Pathways
Its related pathways are Wnt signaling pathway and Adipogenesis.
Function
Soluble frizzled-related protein (sFRPS) directly interacts with Wnts to regulate Wnt signaling. They play a role in regulating cell growth and differentiation (through similarity) of specific cell types. SFRP4 plays a role in bone morphogenesis. It can also be used to regulate the shape and function of the adult uterus. It is also possible to increase apoptosis during ovulation by regulating the FZ1/FZ4/WNT4 signaling pathway (similarity). By specifically inhibiting sodium-dependent phosphate uptake, it has a phosphate effect.
Field of research
Developmental Biology antibody; Signaling Transduction antibody
Post-translational modifications
1.Glycosylation at Asn38, Asn68, Asn116, Asn194, and Asn240 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Clone
BioBet-1282ZP
Description
The anti-SFRP-4 antibody are used for treating or preventing a secreted frizzled related polypeptide type 4-associated disorder. The disorder may be cancers; apoptosis resulting from ischemia, heart failure; myocardial infarction; stroke; neurodegenerative disorder; Huntington's Disease; peripheral demyelinating disease; Multiple Sclerosis; Alzheimer's Disease; Amyotrophic Lateral Sclerosis; Parkinson's Disease; trauma; coronary heart disease; inflammation; or inflammatory bowel disease.
Antibody Indication
Cancer; Heart Failure; Myocardial Infarction; Stroke
