Target
Secreted frizzied related protein 5
Description
Anti-Secreted frizzied related protein 5 Antibody, Non-Fucosylated (BioBet-1283ZP) is a Rabbit monoclonal IgG antibody against Secreted frizzied related protein 5. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Diabetes Mellitus; Hypertension; Cardiac Diseases; Cancers
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Secreted frizzied related protein 5 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Full Name
secreted frizzled-related protein 5
Background
Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas.
Alternative Names
SFRP5; secreted frizzled-related protein 5; SARP3; FRP-1b; SARP-3; sFRP-5; frizzled-related protein 1b; secreted apoptosis related protein 3; secreted apoptosis-related protein 3
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with SFRP5 include Ovarian Clear Cell Adenocarcinoma.
Related Pathways
Its related pathways are Wnt signaling pathway.
Function
Soluble frizzled-related protein (sFRPS) directly interacts with Wnts to regulate Wnt signaling. They play a role in regulating cell growth and differentiation of specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor cells, and may also be involved in the polarity of other cells in the retina.
Post-translational modifications
1.Modification sites at neXtProt 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Clone
BioBet-1283ZP
Description
The anti-SFRP-5 antibody are used for treating diseases related to obesity including but not limited to diabetes mellitus, hypertension, hyperlipoproteinemia, cardiac diseases, pulmonary diseases, cerebrovascular injury, cancers, gall bladder disease, toxemia during pregnancy, risks during surgery, gout, decreased fertility and degenerative arthritis.
Antibody Indication
Diabetes Mellitus; Hypertension; Cardiac Diseases; Cancers
