Anti-S1P Antibody, Highly Galactosylated (CAT#: BioBet-GA-436ZP) Datasheet

S1P

Sonepcizumab; LT1009; humanized Sphingomab; Sphingosine-1-phosphate; S1P

Plasma membrane, Endosome

Its related pathways are Signaling by GPCR and Signaling events mediated by VEGFR1 and VEGFR2.

The biological activity of the G protein-coupled receptor, the lysophospholipid sphingosine 1-phosphate (S1P), appears to be a coupled G(i) subclass isoform G protein. Signal transduction leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. It plays an important role in cell migration, possibly through its role in the formation of lip flaps under the stimulation of actin cytoskeleton reorganization and enhanced sphingosine kinase SPHK1 activity. Required for normal chemotaxis of sphingosine 1-phosphate. This is necessary for normal embryonic heart development and heart morphology. It plays an important role in the regulation of budding, angiogenesis and vascular maturation. Inhibit angiogenesis and prevent excessive angiogenesis during blood vessel development. This is necessary for the normal discharge of mature T cells from the thymus into the bloodstream and surrounding lymphatic organs. Participate in the migration of osteoclast precursor cells, regulate bone mineralization and bone homeostasis (similar). It plays a role in the response of lung endothelial cells to oxidized 1-palmitoyl-2-arachidonic-sn-glycerol-3-phosphocholine and the protection of lung injury induced by ventilator.

S1P-induced endothelial cell migration requires the PKB/AKT1-mediated phosphorylation of the third intracellular loop at the Thr-236 residue.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-GA-436ZP

Humanized

Human

The Highly Galactosylated Anti-S1P (Sonepcizumab), a biobetter antibody contains with a high level of galactosylation.