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Anti-S100A4 Antibody, Non-Fucosylated (BioBet-1257ZP) (CAT#: BioBet-1257ZP) Datasheet

Target
S100A4
Isotype
IgG
Description
Anti-S100A4 Antibody, Non-Fucosylated (BioBet-1257ZP) is a humanized monoclonal IgG antibody against S100A4. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Solid Tumors
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced S100A4 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
S100A4
Full Name
S100 calcium binding protein A4
Background
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Alternative Names
S100A4; S100 calcium binding protein A4; 42A; 18A2; CAPL; FSP1; MTS1; P9KA; PEL98; protein S100-A4; protein Mts1; fibroblast-specific protein-1; placental calcium-binding protein; malignant transformation suppression 1; leukemia multidrug resistance associated protein; S100 calcium-binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog)
Gene ID
6275
Cellular Localization
Extracellular region or secreted, Nucleus
Involvement in Disease
Diseases associated with S100A4 include Bile Duct Adenocarcinoma and Small Intestine Adenocarcinoma.
Related Pathways
Its related pathways are Ca, cAMP and Lipid Signaling.
Field of research
Cancer antibody; Cell Biology and Cellular Response antibody; Signaling Transduction antibody
Post-translational modifications
1.Ubiquitination at Lys57 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1257ZP
Host
Humanized
Species Reactivity
Human
Description
LK-1 is a first-in-class humanized monoclonal antibody directed against S100A4, a soluble protein acting as a key target in the three tumor compartments, and therefore having anti-tumor, anti-metastasis, and anti-angiogenic activities in one drug.
Antibody Indication
Solid Tumors

Solid Tumors

Related Products

Anti-S100A4 Antibody, Non-Fucosylated (BioBet-1258ZP) (CAT#: BioBet-1258ZP)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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