Target
Rh blood group, D antigen
Description
Anti-Rh blood group Antibody, Non-Fucosylated (BioBet-1532ZP) is a human monoclonal IgG antibody against Rh blood group, D antigen. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Haemolytic Disease of The Newborn (HDN)
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Rh blood group, D antigen antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Full Name
Rh blood group, D antigen
Background
The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene, which encodes the RhD protein, and a second gene that encodes both the RhC and RhE antigens on a single polypeptide. The two genes, and a third unrelated gene, are found in a cluster on chromosome 1. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Alternative Names
RHD; Rh blood group, D antigen; RH; Rh4; RH30; RhII; RhPI; DIIIc; RHCED; RHDel; RHPII; RhDCw; CD240D; RHXIII; RHDVA(TT); RhK562-II; blood group Rh(D) polypeptide; D antigen (DCS); RH polypeptide 2; rhesus D antigen; blood group antigen D; Rh blood group, D anitgen; Rhesus system D polypeptide; Rh blood group antigen Evans; Rhesus blood group D antigen allele DIII type 7;
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with RHD include Retinohepatoendocrinologic Syndrome and Hereditary Spherocytosis.
Function
May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.
Post-translational modifications
1.Palmitoylated 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Clone
BioBet-1532ZP
Description
The anti-Rhesus D 5 mononclonal antibody target RhD antigen.And anti-RhD antibody are routinely administered to RhD negative patients for pretecting them from haemolytic disease of the newborn (HDN).
Antibody Indication
Haemolytic Disease of The Newborn (HDN)
