Anti-RGM A Antibody, Non-Fucosylated (BioBet-1568ZP) (CAT#: BioBet-1568ZP) Datasheet

RGMA

repulsive guidance molecule family member a

This gene encodes a member of the repulsive guidance molecule family. The encoded protein is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. This protein may also function as a tumor suppressor in some cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

RGMA; repulsive guidance molecule family member a; RGM; repulsive guidance molecule A; RGM domain family, member A;

Plasma membrane

Diseases associated with RGMA include Hemochromatosis Type 2 and Amusia.

Its related pathways are Netrin-1 signaling and Signaling by BMP.

Members of the Rejection Targeting Molecule (RGM) family, play multiple roles in the developmental and adult nervous system. Regulate the closure of the scalp neural tube, inhibit the growth of neurites, the branching of cortical neurons, and the formation of mature synapses. Binding to the receptor NEO1/neogenin can activate the RHOA-ROCK1/Rho-kinase signaling pathway through the unc5-arhgef12/LARG-PTK2/FAK1 cascade, leading to the breakdown of nerve growth cones and neurite growth inhibition. In addition, RGMA affects the HRAS-ptk2/FAK1-AKT1 pathway and binds to NEO1/neogenin to cause HRAS inactivation. It is also a co-receptor of bone morphogenetic protein (BMP) and may signal through SMAD1, SMAD5 and SMAD8.

1.Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds 2.Modification sites at PhosphoSitePlus 3.Glycosylation at Asn114, Asn159, and Asn389

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

h5F9.21

Humanized

Human

The RGMA binding proteins, particularly monoclonal antibody have the ability to bind to RGMA, and therefore neutralize the function of RGMA, for use in the treatment of retinal nerve fiber layer (RNFL) degeneration.

Retinal Nerve Fiber Layer (RNFL) Degeneration

Retinal Nerve Fiber Layer (RNFL) Degeneration