Anti-Related to receptor tyrosine kinase Antibody, Non-Fucosylated (BioBet-1255ZP) (CAT#: BioBet-1255ZP) Datasheet

RYK

receptor-like tyrosine kinase

The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

RYK; receptor-like tyrosine kinase; JTK5; RYK1; JTK5A; D3S3195; tyrosine-protein kinase RYK; hydroxyaryl-protein kinase; JTK5A protein tyrosine kinase

Nucleus

Diseases associated with RYK include Atypical Chronic Myeloid Leukemia and Robinow Syndrome.

Its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Signaling by GPCR.

It may be a co-receptor for Wnt proteins such as WNT1, WNT3, WNT3A and WNT5A together with FZD8. Participate in the differentiation of neurons, the guidance of axons, the establishment of the corpus callosum and the growth of neurites. As a response to WNT3 stimulation, the cleavage of the receptor c-terminal occurs in the transmembrane region, which transfers the intracellular c-terminal product from the cytoplasm to the nucleus, which plays a key role in neurodevelopment.

1.Proteolytically cleaved, in part by presenilin, in response to WNT3 stimulation. Cleavage occurs during neuronal differentiation 2.Modification sites at PhosphoSitePlus 3.Glycosylation at Asn139, Asn174, Asn178, Asn182, and Asn209

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-1255ZP

Human

Human

The antibody that bind RYK, in particular human RYK are useful in treatment of cancer, inflammation and other chronic diseases and nerve injury, including peripheral nerve injury and spinal cord injury.

Cancer

Cancer