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Anti-Receptor activity modifying protein-3 Antibody, Non-Fucosylated (BioBet-1546ZP) (CAT#: BioBet-1546ZP) Datasheet

Target
Receptor activity modifying protein-3
Isotype
IgG
Description
Anti-Receptor activity modifying protein-3 Antibody, Non-Fucosylated (BioBet-1546ZP) is a mouse monoclonal IgG antibody against Receptor activity modifying protein-3. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Receptor activity modifying protein-3 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
RAMP3
Full Name
receptor (G protein-coupled) activity modifying protein 3
Background
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor. [provided by RefSeq, Jul 2008]
Alternative Names
RAMP3; receptor (G protein-coupled) activity modifying protein 3; receptor activity-modifying protein 3; CRLR activity-modifying protein 3; receptor activity modifying protein 3; receptor-activity-modifying protein 3; receptor (calcitonin) activity modifying protein 3; calcitonin receptor-like receptor activity modifying protein 3; calcitonin-receptor-like receptor activity-modifying protein 3;
Gene ID
10268
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with RAMP3 include Cartilage Cancer and Migraine With Or Without Aura 1.
Related Pathways
Its related pathways are Signaling by GPCR and Myometrial Relaxation and Contraction Pathways.
Function
Reduce myocardial hypertrophy and perivascular fibrosis in a gper1-dependent manner, and protect the heart. The calcitonin gene-related peptide 1 receptor (CALCRL) and GPER1 are transported to the cell membrane. As a receptor for adrenomedullin (AM) and CALCRL.
Post-translational modifications
1.Glycosylation at Asn29, Asn58, Asn71, and Asn103 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1546ZP
Host
Mouse
Species Reactivity
Human
Description
The agent which is capable of binding to more RAMP proteins (Receptor Activity Modifying Protein) selected from (i) a RAMP-3 protein, (ii) a RAMP-2 protein and (iii) a RAMP-1 protein, may be used in the treatment of, for example, cancer, obesity and other disorders.
Antibody Indication
Cancer

Cancer

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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