Anti-R-Spondin 1 Antibody, Non-Fucosylated (BioBet-1594ZP) (CAT#: BioBet-1594ZP) Datasheet

RSPO1

R-spondin 1

This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

RSPO1; R-spondin 1; RSPO; CRISTIN3; R-spondin-1; R-spondin homolog; roof plate-specific spondin-1;

Extracellular region or secreted, Nucleus

Diseases associated with RSPO1 include Palmoplantar Hyperkeratosis With Squamous Cell Carcinoma Of Skin And 46,Xx Sex Reversal and Hermaphroditism.

Its related pathways are Signaling by GPCR and Signaling by Wnt.

As the ligand of LGR4-6 receptor, it activates the typical Wnt signaling pathway (PubMed: 29769720). After binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 binds to phosphorylated LRP6 and frizzled receptors activated by extracellular Wnt receptors, triggering a typical Wnt signaling pathway to increase the expression of target genes. It also regulates the canonical Wnt/ -catenin-dependent pathway and the non-canonical Wnt signal pathway by being an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. As a ligand for curled FZD8 and LRP6. May negatively regulate the tgf-pathway. It plays an important role in the determination of ovaries. By interacting with KREM1, it antagonizes the internalization of LRP6 mediated by DKK1/KREM1 and regulates Wnt signaling.

1.Glycosylation at Asn137 2.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-1594ZP

Human

Human

The antibody that specifically bind human RSPO proteins are used for for treating diseases such as cancer.

Cancer

Cancer