Anti-PSK Antibody, Non-Fucosylated (BioBet-1322ZP) (CAT#: BioBet-1322ZP) Datasheet

TAOK2

TAO kinase 2

This gene encodes a serine/threonine protein kinase that is involved in many different processes, including, cell signaling, microtubule organization and stability, and apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

TAOK2; TAO kinase 2; PSK; PSK1; TAO1; TAO2; MAP3K17; PSK1-BETA; serine/threonine-protein kinase TAO2; PSK-1; hKFC-C; kinase from chicken homolog C; prostate-derived STE20-like kinase 1; prostate derived STE20-like kinase PSK; prostate-derived sterile 20-like kinase 1; thousand and one amino acid protein kinase 2

Cytoskeleton, Nucleus

Diseases associated with TAOK2 include Wilson-Turner X-Linked Mental Retardation Syndrome and Myeloproliferative Syndrome, Transient.

Its related pathways are MAPK signaling pathway and P39 MAPK Signaling Pathway (sino).

Serine/threonine protein kinase is involved in different processes, such as membrane blistering and apoptotic body formation in the DNA damage response and MAPK cascade activated by MAPK14/p38 MAPK stress. Phosphorylate itself, MBP, activate MAPK8, MAP2K3, MAP2K6 and tubulin. Through the specific activation and phosphorylation of upstream MAP2K3 and MAP2K6 kinases, the MAPK14/p38 MAPK signaling pathway is activated. For DNA damage, the MAPK cascade activated by p38/MAPK14 stress may be involved in the G2/M transitional DNA damage checkpoint by mediating the phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not Isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blistering, and apoptotic body formation. This function requires the activation of MAPK8/JNK and the nuclear localization of the c-terminal truncated isoform 1, which may be related to the death pathway related to mitochondrial casp9. Isoform 1 binds to microtubules and affects the organization and stability of microtubules independently of kinase activity. It can inhibit the activation of CHUK mediated by map3k7, thereby inhibiting the activation of nf-kpa-b, but not the activation of MAPK8/JNK. May play a role in the osmotic stress-mapk8 pathway. Heterotype 2, not Heterotype 1, is required for PCDH8 endocytosis. After homophilic interaction between the extracellular domains of PCDH8, isoform 2 phosphorylates and activates MAPK14/p38 MAPK, which in turn phosphorylates isoform 2. This process leads to the co-internalization of PCDH8 and CDH2. Both of these subtypes are involved in the phosphorylation of MAPK14.

Signaling Transduction antibody

Isoforms 1 and 2 are autophosphorylated. C-terminal cleavage of isoform 1 and subsequent nuclear localization requires CASP9 activity. Autophosphorylated. Phosphorylated by ATM. Isoform 2: Phosphorylated on Ser-1031 by MAPK14. This phosphorylation is required PCDH8 for endocytosis (By similarity).

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

5G5

Mouse

Human

The antibody which recognizes PSK and inhibits anti-tumor activity of PSK is useful for detecting and measuring the physiologically active PSK contained in a medicine or a food and drink, and for analyzing pharmacokinetics after administrating the physiologically active PSK.

Cancer

Cancer