Anti-Protein tyrosine phosphatase Sigma Antibody, Non-Fucosylated (BioBet-1527ZP) (CAT#: BioBet-1527ZP) Datasheet

PTPRS

protein tyrosine phosphatase, receptor type, S

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

PTPRS; protein tyrosine phosphatase, receptor type, S; PTPSIGMA; receptor-type tyrosine-protein phosphatase S; R-PTP-S; R-PTP-sigma; protein tyrosine phosphatase PTPsigma; receptor-type tyrosine-protein phosphatase sigma;

Plasma membrane

Diseases associated with PTPRS include Pineal Gland Cancer and Argyll Robertson Pupil.

Its related pathways are Degradation of the extracellular matrix and SALM protein interactions at the synapses.

Cell surface receptors that bind glycosaminoglycans, including chondroitin sulfate proteoglycan and heparan sulfate proteoglycan. Proteoglycan combined with chondroitin sulfate and heparin sulfate has opposite effects on the regulation of polytetrafluoroethylene oligomerization and neurite growth. Chondroitin sulfate proteoglycan can inhibit the growth of neurites and axons. It plays a role in stimulating neurite growth in response to heparan sulfate proteoglycan GPC2. Necessary for the normal development of the brain, especially the normal development of the pituitary gland and olfactory bulb. The function is tyrosine phosphatase. Mediates the dephosphorylation of NTRK1, NTRK2 and NTRK3 (through similarity). Plays a role (through similarity) in down-regulating the signaling cascade that leads to activation of Akt and MAP kinases. Down-regulate tlr9-mediated activation of nf-kpa-b, and the production of TNF, interferon and interferon.

1.A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization (By similarity) 2.Modification sites at PhosphoSitePlus 3.Glycosylation at Asn263, Asn308, Asn733, and Asn940

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

ch13G5-57

Chimeric

Human

The monoclonal antibody that binds to an extracellular domain of human receptor-type protein tyrosine phosphatase σ (human PTPRS) can be used to detect, identify or isolate plasmacytoid dendritic cells (pDCs).

Inflammatory Diseases

Inflammatory Diseases