Target
Protein tyrosine phosphatase beta
Description
Anti-Protein tyrosine phosphatase beta Antibody, Non-Fucosylated (BioBet-1516ZP) is a Rabbit monoclonal IgG antibody against Protein tyrosine phosphatase beta. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Diabetic macular edema
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Protein tyrosine phosphatase beta antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Full Name
protein tyrosine phosphatase, receptor type, B
Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Alternative Names
PTPRB; protein tyrosine phosphatase, receptor type, B; PTPB; HPTPB; VEPTP; HPTP-BETA; R-PTP-BETA; receptor-type tyrosine-protein phosphatase beta; VE-PTP; vascular endothelial protein tyrosine phosphatase; protein tyrosine phosphatase, receptor type, beta polypeptide;
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with PTPRB include Generalized Epilepsy With Febrile Seizures Plus, Type 1 and Skin Angiosarcoma.
Related Pathways
Its related pathways are Activation of cAMP-Dependent PKA and Innate Immune System.
Function
It plays an important role in vascular remodeling and angiogenesis. It is not a necessary condition for the initial formation of blood vessels, but it is necessary for the maintenance and remodeling of blood vessels. It can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulate endothelial cell angiopoietin-tie2 signal. As a negative regulator of TIE2, it controls the proliferation of endothelial cells driven by TIE2, which in turn affects vascular remodeling during embryonic development and determines the size of blood vessels in the perinatal period. It is essential to maintain the contact integrity of endothelial cells and the adhesion function of VE-cadherin in endothelial cells, which requires the presence of plakoglobin (similar).
Post-translational modifications
1.Glycosylation at Asn28, Asn53, Asn75, Asn172, Asn198, Asn267, Asn321, Asn479, Asn414, Asn421, Asn544, Asn574, Asn598, Asn652, Asn721, Asn829, Asn1040, Asn1096, Asn1163, Asn1185, Asn1212, Asn1274, Asn1367, Asn1470, Asn1474, and Asn1518 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Clone
BioBet-1516ZP
Description
This antibody is expected to recognize both reported isoforms of protein tyrosine phosphatase, receptor type, beta polypeptide (PTPRB), which is critical in physiological and pathological events such as cell migration, adhesion and transformation.
Antibody Indication
Diabetic macular edema
