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Anti-Protease-activated receptor 1 Antibody, Non-Fucosylated (BioBet-852ZP) (CAT#: BioBet-852ZP) Datasheet

Target
Protease-activated receptor 1
Isotype
IgG
Description
Anti-Protease-activated receptor 1 Antibody, Non-Fucosylated (BioBet-852ZP) is a humanized monoclonal IgG antibody against Protease-activated receptor 1. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Protease-activated receptor 1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
F2R
Full Name
coagulation factor II (thrombin) receptor
Background
Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member.
Alternative Names
F2R; coagulation factor II (thrombin) receptor; TR; HTR; CF2R; PAR1; PAR-1; proteinase-activated receptor 1; protease-activated receptor 1
Gene ID
2149
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with F2R include Thrombosis and Bernard-Soulier Syndrome.
Related Pathways
Its related pathways are RET signaling and Signaling by GPCR.
Function
High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.
Post-translational modifications
A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand. Phosphorylated in the C-terminal tail; probably mediating desensitization prior to the uncoupling and internalization of the receptor.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-852ZP
Host
Humanized
Species Reactivity
Human
Description
This is an antibody which binds specifically PAR1 (protease activated receptor 1), used for inhibiting the migration activity and invasion activity of cancer cells and treating cancer.
Antibody Indication
Cancer

Cancer

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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