Description
Anti-Prostate-specific antigen Antibody, Non-Fucosylated (BioBet-1148ZP) is a humanized monoclonal IgE antibody against Prostate-specific antigen. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Prostate Cancer
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Prostate-specific antigen antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
KLK3
Full Name
kallikrein-related peptidase 3
Background
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms.
Alternative Names
KLK3; kallikrein-related peptidase 3; APS; PSA; hK3; KLK2A1; prostate-specific antigen; seminin; P-30 antigen; kallikrein-3; semenogelase; gamma-seminoprotein; prostate specific antigen
Gene ID
354
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with KLK3 include Prostatitis and Urethral Stricture.
Related Pathways
Its related pathways are Signaling by GPCR and Translation Non-genomic (rapid) action of Androgen Receptor.
Function
Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
Field of research
Cancer antibody; Controls and Markers antibody; Neuroscience antibody; Signaling Transduction antibody
Post-translational modifications
1.Glycosylation at Asn69 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgE
Antibody Clone
BioBet-1148ZP
Description
The anti-PSA monoclonal IgE is a novel therapy for prostate cancer. The data demonstrate the potential ability of the novel molecule to selectively open the circulation which may improve the ability of cytotoxic therapy to reach cancers. At the same time, the antibody can activate specific cellular immune responses directed against PSA originating in the tumor.
Antibody Indication
Prostate Cancer
