Target
Prostaglandin E2 receptor subtype EP4
Description
Anti-Prostaglandin E2 receptor subtype EP4 Antibody, Non-Fucosylated (BioBet-1509ZP) is a Rabbit monoclonal IgG antibody against Prostaglandin E2 receptor subtype EP4. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Osteoclastogenesis; Skeletal Abnormalities
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Prostaglandin E2 receptor subtype EP4 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Full Name
prostaglandin E receptor 4 (subtype EP4)
Background
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]
Alternative Names
PTGER4; prostaglandin E receptor 4 (subtype EP4); EP4; EP4R; prostaglandin E2 receptor EP4 subtype; prostanoid EP4 receptor; PGE receptor EP4 subtype; PGE receptor, EP4 subtype; PGE2 receptor EP4 subtype;
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with PTGER4 include Malignant Epithelial Mesothelioma and Penis Basal Cell Carcinoma.
Related Pathways
Its related pathways are Eicosanoid ligand-binding receptors and Signaling by GPCR.
Function
Prostaglandin E2 (PGE2) receptor. The activity of this receptor is mediated by G(s) protein, which stimulates adenylate cyclase. It has a relaxing effect on smooth muscles. It may play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion and uterine function.
Field of research
Signaling Transduction antibody
Post-translational modifications
Phosphorylation mediates agonist-mediated desensitization by promoting cytoplasmic retention.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Clone
BioBet-1509ZP
Description
The antibody targets EP4 which is PGE2 receptor and which is the critical receptor involved in the stimulation of osteoclast formation and activity.The product can be used for osteoclastogenesis, skeletal abnormalities.
Antibody Indication
Osteoclastogenesis; Skeletal Abnormalities
