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Anti-Prostaglandin E2 Antibody, Non-Fucosylated (BioBet-1639ZP) (CAT#: BioBet-1639ZP) Datasheet

Target
Prostaglandin E2
Isotype
IgG
Description
Anti-Prostaglandin E2 Antibody, Non-Fucosylated (BioBet-1639ZP) is a mouse monoclonal IgG antibody against Prostaglandin E2. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Inflammation; Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Prostaglandin E2 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
PGE2
Full Name
Prostaglandin E2
Background
The naturally occurring prostaglandin E2 (PGE2 or PGE2) is known in medicine as dinoprostone. It has important effects in labour (softening the cervix and causing uterine contraction) and also stimulates osteoblasts to release factors that stimulate bone resorption by osteoclasts. PGE2 is also the prostaglandin that ultimately induces fever.PGE2 also suppresses T cell receptor signaling and may play a role in resolution of inflammation.
Alternative Names
PGE2; Prostaglandin E2; PGE2
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with PTGER2 include Asthma, Nasal Polyps, And Aspirin Intolerance and Asthma.
Related Pathways
Its related pathways are Eicosanoid ligand-binding receptors and Signaling by GPCR.
Function
Prostaglandin E2 (PGE2) receptor. The activity of this receptor is mediated by G(s) protein, which stimulates adenylate cyclase. The subsequent increase in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.
Post-translational modifications
1.Glycosylation at Asn3, Asn6, Asn96, and Asn287 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1639ZP
Host
Mouse
Species Reactivity
Human
Description
The preferred antibody have high affinity for prostaglandin E2. They are useful for detecting prostaglandin E2 and for inhibiting prostaglandin E2 activity in the treatment of inflammation and cancer.
Antibody Indication
Inflammation; Cancer

Inflammation; Cancer

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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