Description
Anti-Properdin Antibody, Non-Fucosylated (BioBet-705ZP) is a humanized monoclonal IgG antibody against Properdin. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Arthritis
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Properdin antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CFP
Full Name
complement factor properdin
Background
This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Alternative Names
CFP; complement factor properdin; BFD; PFC; PFD; PROPERDIN; properdin; complement factor P; properdin P factor, complement
Gene ID
5199
UniProt ID
P19022
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with CFP include Properdin Deficiency, X-Linked and Properdin Deficiency.
Related Pathways
Its related pathways are Metabolism of proteins and Innate Immune System.
Function
Positive regulator of the complement replacement pathway (AP). It binds and stabilizes the C3 and C5 conversion enzyme complex. Inhibit CFI-CFH-mediated degradation of complement C3 beta chain (C3b).
Field of research
Microbiology and Infectious Disease antibody
Post-translational modifications
1.Glycosylation at Trp83, Trp86, Thr92, Trp139, Trp142, Trp145, Thr151, Trp196, Trp199, Ser208, Trp260, Trp263, Thr272, Trp321, Trp324, Trp382, Trp385, Trp388, and Asn428 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-705ZP
Description
The antibody specific to properdin and the use of such antibody to inhibit alternative complement pathway function in a mammal.
Antibody Indication
Arthritis
