Anti-Prominin-1 Antibody, Non-Fucosylated (293C3-SDIE) (CAT#: BioBet-1542ZP) Datasheet

PROM1

prominin 1

This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

PROM1; prominin 1; RP41; AC133; CD133; MCDR2; STGD4; CORD12; PROML1; MSTP061; prominin-1; hProminin; antigen AC133; prominin-like protein 1; hematopoietic stem cell antigen;

Plasma membrane, Endoplasmic reticulum

Diseases associated with PROM1 include Macular Dystrophy, Retinal, 2 and Stargardt Disease 4.

Its related pathways are Transcriptional misregulation in cancer and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers.

May be involved in cell differentiation, proliferation and apoptosis. Cholesterol is bound in the plasma membrane microdomains containing cholesterol and may play a role in the apical plasma membrane tissue of epithelial cells. It is a key regulator of intervertebral disc morphology during early retinal development. Involved in the regulation of MAPK and Akt signaling pathways. In neuroblastoma, cells inhibit cell differentiation, such as neurites growing in a ret-dependent manner.

Cancer antibody; Cell Death antibody; Gene Regulation antibody

Isoform 1 and isoform 2 are glycosylated. Acetylation at Lys-225, Lys-257 and Lys-264 by NAT8 and NAT8B may control PROM1 protein expression and its function in cell apoptosis.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

293C3-SDIE

Chimeric

Human

The product is anl antibody which targets the cholesterol-binding transmembrane glycoprotein CD 133 which expressed on the cell surface of somatic stem cells. And it can be used as a class of therapeutic proteins that may be used to treat cell-proliferative diseases and disorders, in particular those affecting the hematopoietic system.

Acute myeloid leukemia

Acute myeloid leukemia