Description
Anti-Prominin-1 Antibody, Non-Fucosylated (BioBet-1542ZP) is a chimeric monoclonal IgG antibody against Prominin-1. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Acute myeloid leukemia
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Prominin-1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
PROM1
Full Name
prominin 1
Background
This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Alternative Names
PROM1; prominin 1; RP41; AC133; CD133; MCDR2; STGD4; CORD12; PROML1; MSTP061; prominin-1; hProminin; antigen AC133; prominin-like protein 1; hematopoietic stem cell antigen;
Gene ID
8842
Cellular Localization
Plasma membrane, Endoplasmic reticulum
Involvement in Disease
Diseases associated with PROM1 include Macular Dystrophy, Retinal, 2 and Stargardt Disease 4.
Related Pathways
Its related pathways are Transcriptional misregulation in cancer and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers.
Function
May be involved in cell differentiation, proliferation and apoptosis. Cholesterol is bound in the plasma membrane microdomains containing cholesterol and may play a role in the apical plasma membrane tissue of epithelial cells. It is a key regulator of intervertebral disc morphology during early retinal development. Involved in the regulation of MAPK and Akt signaling pathways. In neuroblastoma, cells inhibit cell differentiation, such as neurites growing in a ret-dependent manner.
Field of research
Cancer antibody; Cell Death antibody; Gene Regulation antibody
Post-translational modifications
Isoform 1 and isoform 2 are glycosylated. Acetylation at Lys-225, Lys-257 and Lys-264 by NAT8 and NAT8B may control PROM1 protein expression and its function in cell apoptosis.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
293C3-SDIE
Description
The product is anl antibody which targets the cholesterol-binding transmembrane glycoprotein CD 133 which expressed on the cell surface of somatic stem cells. And it can be used as a class of therapeutic proteins that may be used to treat cell-proliferative diseases and disorders, in particular those affecting the hematopoietic system.
Antibody Indication
Acute myeloid leukemia
