Target
Programmed Cell Death 1 Ligand 2
Description
Anti-Programmed Cell Death 1 Ligand 2 Antibody, Non-Fucosylated (BioBet-1574ZP) is a human monoclonal IgG antibody against Programmed Cell Death 1 Ligand 2. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Autoimmune Diseases; Asthma; Inflammatory disorders; Tumors
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Programmed Cell Death 1 Ligand 2 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Full Name
programmed cell death 1 ligand 2
Alternative Names
PDCD1LG2; programmed cell death 1 ligand 2; B7DC; Btdc; PDL2; CD273; PD-L2; PDCD1L2; bA574F11.2; B7-DC; PD-1 ligand 2; PD-1-ligand 2; PDCD1 ligand 2; butyrophilin B7-DC; programmed death ligand 2; B7 dendritic cell molecule;
Cellular Localization
Plasma membrane, Extracellular region or secreted
Involvement in Disease
Diseases associated with PDCD1LG2 include Cysticercosis and Testicular Lymphoma.
Related Pathways
Its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.
Function
Participating in costimulatory signals is essential for the proliferation of T cells and the production of IFNG, and does not depend on pdcd1. The interaction with PDCD1 inhibits T cell proliferation by blocking cell cycle progression and cytokine production (through similarity).
Post-translational modifications
1.Glycosylation at Asn37, Asn64, Asn157, Asn163, and Asn189 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Clone
BioBet-1574ZP
Description
The anti-PD-L2 antibody is against PD-L2 which are ligands for PD-1. It can be used to detect and isolate PD-L2 proteins, regulate the bioavailability of PD-L2 proteins, and modulate PD-L2 activity, with the use of treatment for persistent infectious diseases, autoimmune diseases, asthma, transplant rejection, inflammatory disorders and tumors.
Antibody Indication
Autoimmune Diseases; Asthma; Inflammatory disorders; Tumors
