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Anti-Pro104 Antibody, Non-Fucosylated (Pro104.D9) (CAT#: BioBet-1552ZP) Datasheet

Target
Pro104
Isotype
IgG
Description
ADCC-Enhanced anti-Pro104 (Pro104.D9) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Pro104 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
PRSS21
Full Name
protease, serine, 21 (testisin)
Background
This gene encodes a cell-surface anchored serine protease, which is a member of the trypsin family of serine proteases. The encoded protein is predicted to be active on peptide linkages involving the carboxyl group of lysine or arginine. The encoded protein localizes to the cytoplasm and the plasma membrane of premeiotic testicular germ cells and may be involved in progression of testicular tumors of germ cell origin. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Alternative Names
PRSS21; protease, serine, 21 (testisin); ESP1; ESP-1; TEST1; TESTISIN; testisin; eosinophil serine protease 1; serine protease from eosinophils;
Gene ID
10942
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with PRSS21 include Gastric Cancer and Chronic Salpingo-Oophoritis.
Related Pathways
Its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins.
Function
Could regulate proteolytic events associated with testicular germ cell maturation.
Post-translational modifications
1.Glycosylation at Asn167, Asn200, and Asn273 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
Pro104.D9
Host
Mouse
Species Reactivity
Human
Description
The products are anti-ovarian, pancreatic, lung or breast cancer antigen (Pro104) antibody that bind to Pro104 on a mammalian cell in vivo. They may be therapeutic reagents of alleviating or treating a Pro104-expressing cancer.
Antibody Indication
Cancer

Cancer

Related Products

Anti-Pro104 Antibody, Non-Fucosylated (Pro104.C25.1) (CAT#: BioBet-1550ZP)
Anti-Pro104 Antibody, Non-Fucosylated (Pro104.D133) (CAT#: BioBet-1551ZP)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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