Description
Anti-Presenilin 2 Antibody, Non-Fucosylated (BioBet-1507ZP) is a Rabbit monoclonal IgG antibody against Presenilin 2. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Alzheimer's Disease
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Presenilin 2 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Background
Alzheimers disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]
Alternative Names
PSEN2; presenilin 2; AD4; PS2; AD3L; STM2; CMD1V; presenilin-2; AD5; E5-1; PS-2; AD3LP; STM-2; Alzheimer disease 4;
Cellular Localization
Golgi apparatus, Endoplasmic reticulum
Involvement in Disease
Diseases associated with PSEN2 include Alzheimer Disease 4 and Cardiomyopathy, Dilated, 1V.
Related Pathways
Its related pathways are Neuroscience and Signaling by GPCR.
Function
It may be the catalytic subunit of the secretase complex, a protease complex that catalyzes the intramembrane cleavage of intact membrane proteins, such as Notch receptors and APP (amyloid precursor protein). The other members of the secretase complex are required to have protease activity. It may play a role in intracellular signal transduction and gene expression or connecting chromatin to the nuclear membrane. May play a role in the cytoplasmic distribution of proteins. Whole protein acts as a calcium leakage channel, allowing calcium to move passively from the endoplasmic reticulum to the cytoplasm and participate in calcium homeostasis. It is a regulator of mitochondria-endoplasmic reticulum membrane, which restricts and regulates the calcium ions that shuttle between ER and mitochondria.
Post-translational modifications
Heterogeneous proteolytic processing generates N-terminal and C-terminal fragments. Phosphorylated on serine residues.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Clone
BioBet-1507ZP
Description
Anti-Presenilin 2 antibody targets Pren, which is expressed in a wide range of tissues including the heart, brain, placenta, liver, skeletal muscle and kidney, may be used to treat for Alzheimer's Disease and cardiomyopathy dilated type 1V (CMD1V).
Antibody Indication
Alzheimer's Disease
